Lipid Profile Panel This test various types of lipids like Triglycerides, Total Cholesterol , HDL and LDL high-density lipoprotein (HDL), or “good” cholesterol low-density lipoprotein (LDL), or “bad” cholesterol HDL is “good” because it removes harmful substances from your blood and helps the liver break them down into waste. LDL is “bad” because it can cause plaque to develop in your arteries, increasing your risk of heart disease. You need to fast for at least 12 hours before this test.